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医学翻译样例(14)

发表时间:2019-1-26  浏览次数:176  
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原文:
The leading reasons for stopping preventive treatment were pregnancy (accounting for 34 patients), initiation of highly active antiretroviral therapy (27 patients, all in the continuous-isoniazid group), and withdrawal from the study because of work responsibilities (14 patients). The types and rates of adverse events are shown in Table 3. For the three shorter regimens, almost all adverse events occurred after completion of treatment, whereas 87.3% of adverse events in the continuous-isoniazid group occurred during the medication phase. Rates of serious adverse events (grade 3 or 4 toxic effects, death, and active tuberculosis) while patients were receiving the study drugs were 8.7 per 100 person-years in the rifapentine–isoniazid group, 10.6 per 100 person-years in the rifampin–isoniazid group, 18.4 per 100 person-years in the continuous-isoniazid group, and 15.4 per 100 person-years in the 6-month–isoniazid group (P>0.05 for all comparisons with the 6-month–isoniazid group). There were no deaths attributed to a study drug. A grade 3 or 4 elevation in the aspartate or alanine aminotransferase level occurred during the treatment phase in 1.5%, 2.4%, 28.0%, and 5.5% of patients in the rifapentine–isoniazid, rifampin–isoniazid, continuous- isoniazid, and 6-month–isoniazid groups, respectively (P<0.001 for the comparison of continuous isoniazid with 6-month isoniazid). The median time from randomization to the first detected grade 3 or 4 elevation in the aminotransferase level was 47 days (interquartile range, 36 to 57), 28 days (interquartile range, 8 to 68), 571 days (interquartile range, 358 to 674), and 175 days (interquartile range, 56 to 182) in the rifapentine–isoniazid, rifampin–isoniazid, continuous-isoniazid, and 6-month–isoniazid groups, respectively.

译文:
终止研究的主要原因包括怀孕(共计34人)、实施高效抗逆转录病毒治疗(27人,均来自持续异烟肼给药组)及因工作原因退出研究(14人)等。不良反应类型及发病率如表3所示。治疗时间相对较短的三组,多数不良反应出现在治疗结束后;而在持续给药组87.3%的不良反应发生在给药期间。利福喷汀-异烟肼组恶性不良反应(3级或4级毒性效应、死亡及活动性结核)年发病率为8.7%,利福平-异烟肼组为10.6%,持续异烟肼给药组为18.4%,异烟肼给药6个月组(对照组)为15.4%。治疗组与对照组相比组间无差异。研究期间未发现药物致死病例。利福喷汀-异烟肼组、利福平-异烟肼组、持续异烟肼给药组及对照组天冬氨酸或丙氨酸氨基转移酶水平升高3-4级的患者比例分别为1.5%、2.4%、28.0%及5.5%。其中,持续异烟肼给药组与对照组相比存在显著性差异。各组随机化至首次检测到氨基转移酶水平升高3-4级所用的平均时间分别为47天(四分差:36-57)、28天(四分差:8-68)、571天(四分差:358-674)及175天(四分差:56-182)。

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