英语助手母语润色网
查找母语润色产品
立即注册
下单注意事项

医学翻译样例(1)

发表时间:2019-1-9  浏览次数:274  
字体大小: 【小】 【中】 【大】

原文:
The  use  of defined adjuvants that target pathogen recognition receptors on APCs to induce specific subsets of cells  is essential to induce specific cellular responses by  vaccination. In this respect, complete Freund’s adjuvant (CFA) has  been used for a long time in research as  it is a potent inducer of cell-mediated inflammatory responses. Since   heat killed Mtb   is  a  major component of  CFA, understanding how specific elements of this adjuvant target cells and stimulate infiammation will  help in  adjuvant design. Recent exciting work has  defined the pathway by which one of the major components of  Mtb   cell  wall, Trehalose-6,60 -dimycolate  (TDM; Cord  factor) induces cell-mediated infiammatory responses.  These results showed that the C-type lectin Mincle is central for TDM to induce infiammatory responses and both Th1 and Th17 acquired immunity. Indeed, Trehalose-6,6-dibehenate (a synthetic analogue of TDM) and TDM stimulation of macrophages were shown to  induce IL-12p40, IL-12p70, IL-23,  IL-1b, IL-6 and TNF production in  a MyD88-independent way but dependent on Mincle signaling through Syk-FcRg-CARD9. Interestingly, it has   been suggested that T cells   can  also  respond to  TDM  as Mincle is expressed in  T cells  upon activation.  It is possible that  direct T  cell   recognition  of  TDM  induces  production  of cytokines such as IFN-g, IL-17 or IL-1b. In line with this, it has been shown that direct T cell  stimulation through TLR2 promotes Th17 differentiation in vitro and more robust Th17  cytokine production.

译文:
病原体识别受体靶向性药物可诱导特定细胞群产生特定细胞应答。因此,常使用弗氏完全佐剂作为细胞解答炎症应答的诱导因子。热灭活的结核分枝杆菌为CFA的主要组分之一。明确CFA特定组分在刺激炎症方面的作用将有利于改善佐剂的功效。近期一项研究表明,作为Mtb细胞壁的主要成分之一,海藻糖二霉菌酸酯可诱导细胞介导的炎症应答。这些结果表明,C型凝集素在海藻糖二霉菌酸酯诱导炎症应答中有重要作用。此外,在Th1细胞与Th17细胞获得性免疫作用中也具备重要作用。 TDM的类似物及TDM对巨噬细胞的刺激可诱导IL-12p40、IL-12p70、IL-23、IL-1b、IL-6 与TNF表达,该表达存在MyD88依赖。此外,T细胞也可对TDM产生应答。  TDM对T细胞的直接识别可诱导细胞因子表达,如γ-干扰素、IL-17或IL-1β。与此相符的是,T细胞直接刺激(通过TLR2实施)可促进Th17细胞体外分化,并增强Th17细胞因子的表达。

文章评论
发表评论:(匿名发表无需登录,已登录用户可直接发表。) 登录状态: 未登录,点击登录

地址:上海徐汇区田林东路55号汇阳广场20楼C23和C22室(英文论文润色服务) 热线电话:400-0871-070

旗下母公司:上海译境翻译服务有限公司   联系电话:021-6131 4984

                            英语助手英文论文润色官方网版权所有沪ICP备14046471号-1 © 2007-2027 E-ging All Rights Reserved.

                           咨询电话:137 6474 0063      咨询QQ:229632732          服务邮箱:info@e-ging.xyz