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发表时间:2019-1-7  浏览次数:39  
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原文:
Maternal infection during pregnancy increases the risk of schizophrenia and other brain disorders of neurodevelopmental origin in the offspring. A multitude of infectious agents seem to be involved in this association. Therefore, it has been proposed that factors common to the immune response to a wide variety of bacterial and viral pathogens may be the critical link between prenatal infection and postnatal brain and behavioral pathology. More specifically, it has been suggested that the maternal induction of pro-inflammatory cytokines may mediate the neurodevelopmental effects of maternal infections. Here, we review recent findings from in vitro and in vivo investigations supporting this hypothesis and further emphasize the influence of enhanced anti-inflammatory cytokine signaling on early brain development. Disruption of the fetal brain balance between pro- and anti-inflammatory cytokine signaling may thus represent a key mechanism involved in the precipitation of schizophrenia-related pathology following prenatal maternal infection and innate immune imbalances.

 

译文:
妊娠期母性感染会增加后代精神分裂症及其他脑部疾病的风险。大量感染因子与此相关。 因此,对细菌及病毒病原体产生免疫应答的细胞因子与母体感染、产后脑部病理及行为学病理机制关系密切。 此外,研究表明母体感染致炎性细胞因子可能影响会影响胎儿神经发育。本文对支持该假说的体内及体外实验进行综述,同时进一步强调抗炎性细胞因子信号增强对早期脑发育的影响。新生儿母体感染与先天性免疫失调与精神分裂症相关病理机制相关。胎儿脑部致炎性细胞因子与抗炎性细胞因子信号失衡可能与之密切相关。

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