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发表时间:2019-1-5  浏览次数:44  
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原文:
Previous studies of lymphocyte distribution in schizophrenia have yielded inconsistent results, as summarized in the present study. Based on our own original data, potential confounds that might explain these variations are analyzed and discussed. Blood samples from 26 patients with acute paranoid schizophrenia were investigated in comparison with 32 matched healthy controls by flow cytometry (CD3, CD4, CD8, CD19, and CD56 phenotyping). A subgroup of drug-free patients was followed up after 6 weeks of treatment. Cotinine levels and the free cortisol index (FCI) were provided in order to control for medication, smoking, and stress. Cotinine levels correlated with natural killer (NK) cell counts (CD3⁻/CD56(+): r = -0.383, P = 0.003) while the FCI was related to B cell numbers (CD19(+): r = 0.390, P = 0.003). Considering these covariates, a lower level of T helper cells (P = 0.010), a reduced CD4/CD8 ratio (P = 0.029), and elevated B cells (P = 0.008) were found during acute psychosis. After 6 weeks of medication, an inverse pattern was observed in initially drug-free patients: total T cell (P = 0.005), T helper (P = 0.003), and T suppressor/cytotoxic cells (P = 0.005) increased, while B cell counts declined (P = 0.049). In conclusion, acute paranoid schizophrenia may be accompanied by a reduced T cell defense and a shift towards B cell immunity, which normalizes in response to treatment. In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors.
译文:
既往精神分裂症患者体内淋巴细胞分布的相关报道存在一定差异(详见本文)。根据本文的原始数据,我们对可能解释分布差异的一些易混淆问题开展分析与讨论。利用流式细胞术,我们对26例偏执型精神分裂症患者的血样与32例匹配健康对照进行对比,比较CD3、CD4、CD8、CD9与CD56表型。治疗6周后,对未治疗患者实施随访。测定可替宁水平与游离皮质醇指数(FCI),以对患者用药、吸烟及压力实施对照。可替宁水平与NK细胞计数相关(CD3⁻/CD56+:r = -0.383,P = 0.003)。FCI与B细胞计数相关(CD19+:r = 0.390,P = 0.003)。根据这些协变量,我们发现急性精神病发作期间患者T辅助细胞水平降低(P = 0.010),CD4/CD8比值降低(P = 0.029),B细胞数量升高(P = 0.008)。服药6周后,早期未治疗患者体内细胞变化模式恰好相反:总体T细胞(P = 0.005)、T辅助细胞(P = 0.003)与CD8+T细胞(P = 0.005)水平增加,而B细胞计数降低(P = 0.049)。结论:标准化治疗期间,急性偏执型精神分裂症患者可能伴有T细胞防御功能降低与B细胞免疫功能改变。除疾病分期与用药外,吸烟与压力也是影响研究的重要辅助因素。

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