英语助手母语润色网
查找母语润色产品
立即注册
下单注意事项

文献检索样例(4)

发表时间:2019-1-4  浏览次数:153  
字体大小: 【小】 【中】 【大】
原文:
Bipolar disorder (BPD) and schizophrenia (SCZ) are severe disorders representing an enormous social, familiar and individual burden, being SCZ the most disabling psychiatric disorder characterized by psychosis and cognitive impairment. It is well known that SCZ and BPD are associated with abnormalities in dopamine signaling pathway. Recent data in the literature have demonstrated altered expression levels of some proteins involved in the modulation of this pathway in both brain and peripheral tissues. It was shown that protein and mRNA levels of dopamine and cAMP regulated phosphoprotein (DARPP-32) were downregulated in dorsolateral prefrontal cortex (DLPFC) of patients with SCZ or BPD when compared to controls. Due to the difficulty to access brain tissue and the absence of objective laboratory tests for bio-markers, we measured DARPP-32 expression in blood cell sub-populations (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) taking advantage of the close relation of nervous and immune systems. Using flow cytometry as the analytical method, our results have shown that the DARPP-32 expression was diminished in CD4+ T lymphocytes, CD19+ B lymphocytes and CD14+ monocytes of BPD patients and was also decreased in CD4+ T lymphocytes and CD56+ NK cells of SCZ patients. These results showed that DARPP-32 expression in immune cells agrees with reports of reduced DARPP-32 protein in the DLPFC of BPD or SCZ patients. Our data suggest that DARPP-32 expression in PBMC could be used as a source of bio-markers to help in the treatment response of neuropsychiatry disorders as a window to the changes in the brain of those patients.
 
译文:
双相情感障碍(BPD)与精神分裂症(SCZ)给社会、家庭及患者本人造成了极大的心理负担。其中SCZ易使人发生精神异常,给患者的精神、认知状态带来极大损伤。众所周知,SCZ与BPD与患者多巴胺信号通路异常相关。近来有研究表明某些蛋白表达量的变化可影响脑与周围组织内多巴胺信号通路的调控。另外,与对照组相比,SCZ患者或BPD患者大脑背外侧前额叶皮质(DLPFC)内多巴胺/cAMP调节的磷蛋白(DARPP-32)水平及mRNA水平出现下调。 鉴于实施研究时难以深入脑组织,且缺乏相应的生物标记实验室检测手段,我们对血细胞亚群(包括CD4+T淋巴细胞、CD56+NK细胞、CD19+B淋巴细胞及CD14+单核细胞)内的DARPP-32表达进行测定。利用流式细胞术我们发现,BPD患者体内CD4+T淋巴细胞、CD19+B淋巴细胞及CD14+单核细胞内DARPP-32表达降低,而SCZ患者CD4+T淋巴细胞与CD56+NK细胞内表达量也有所降低。表明免疫细胞内DARPP-32表达变化与BPD或SCZ患者DLPFC内DARPP-32蛋白表达量降低一致。本研究结果表明外周血单个核细胞内DARPP-32表达可作为神经精神障碍治疗的一项生物标记(可介导患者脑部变化)。
文章评论
发表评论:(匿名发表无需登录,已登录用户可直接发表。) 登录状态: 未登录,点击登录

地址:上海徐汇区田林东路55号汇阳广场20楼C23和C22室(英文论文润色服务) 热线电话:400-0871-070

旗下母公司:上海译境翻译服务有限公司   联系电话:021-6131 4984

                            英语助手英文论文润色官方网版权所有沪ICP备14046471号-1 © 2007-2027 E-ging All Rights Reserved.

                           咨询电话:137 6474 0063      咨询QQ:229632732          服务邮箱:info@e-ging.xyz