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发表时间:2019-1-3  浏览次数:46  
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原文:
Background and purpose: Autoimmune process is thought to be involved in the pathophysiology in some cases of schizophrenia. Alteration in interleukin (IL) regulation is regarded as additional proof of autoimmunological background in schizophrenia. Most of the research in interleukin activity in schizophrenia
has been in Caucasian and some Mongoloid patients. We have studied the serum IL-2 and IL-6 level in psychotropic medication free and antipsychotic medicating schizophrenic patients who are Indian Bengalee by ethnicity. Method: Twenty psychotropic medication free and 30 antipsychotic medicating schizophrenic patients who fulfilled DSM-IV-TR criteria and 30 of the same age and sex matched controls were recruited. Serum level of IL-2 and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Result: There was a significant decrease of IL-2 and IL-6 in both antipsychotic medicating and psychotropic medication free patients. Further the medicating patients showed lower level of IL-2 and IL-6 than the psychotropic medication free patients. Conclusion: This is the first study to describe a decrease serum level of IL-6 in schizophrenic patients. The study provides the evidence that some kind of immune dysregulation is involved in pathophysiology of schizophrenia. The study also provides the evidence for the immunosuppressive effect of antipsychotic drugs.

 

译文:
目的:自身免疫与精神分裂症发病机制存在一定关系。白介素(IL)调控改变常被视为精神分裂症患者自身免疫调控异常的辅助依据。大多数关于精神分裂症患者白介素活性的研究主要针对高加索人与蒙古人。本文对印度孟加拉籍精神分裂症患者(未治疗患者与服药患者)的血清IL-2与IL-6水平进行研究。
方法:本研究纳入20名未治疗患者、30名服药精神分裂症患者,均符合精神疾病诊断准则手册(DSM-IV-TR)规定标准。此外,纳入30名年龄与性别匹配的健康受试者作为对照。 通过酶联免疫吸附(ELISA)测定IL-2与IL-6水平。
结果:两组患者IL-2与IL-6水平明显降低。与未治疗患者相比,服药患者IL-2与IL-6水平更低。
结论:该研究首次报道精神分裂症患者IL-6水平有所降低。该研究证实精神分裂症与免疫失调在病理学方面相关。此外,本研究也为抗精神病药物免疫抑制功效提供了依据。

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