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发表时间:2019-1-1  浏览次数:206  
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原文:
Aberrant activation of the immune system has been implicated in an increasingly large number of disease states and can influence cognition, mood, and memory. There is a long and controversial history of reports of immune activation associated with schizophrenia. In this study, we measured mitogen-stimulated cytokine levels serially in 100 medication-stabilized continuously ill subjects with schizophrenia and compared and contrasted them with mitogen-stimulated cytokine levels from 51 normal volunteers. The subjects with schizophrenia had consistently higher mitogen-stimulated IL-2 levels and lower IL-6 levels than the normal volunteers. These effects could not be explained by medications, smoking, or other clinical variables. We conclude that continuously symptomatic medication-stabilized subjects with schizophrenia have a mitogen-stimulated cytokine expression pattern that is suggestive of ongoing immune activation.


译文:
免疫系统异常激活与多种疾病相关,对患者的认知、情绪及记忆力造成一定影响。早期就有报道称免疫激活与精神分裂症相关,但尚无定论。本研究对100名精神分裂症患者(持续服药后病情维持稳定)体内丝裂原诱发细胞因子水平变化进行测定,并与51名健康受试者体内的丝裂原刺激细胞因子水平进行比较。与健康受试者相比,患者体内丝裂原诱发的白介素-2(IL-2)水平较高,而IL-6水平相对较低。该效应不受用药、吸烟或其他临床因素的影响。我们认为精神分裂症患者(持续服药病情稳定)体内丝裂原诱导细胞因子表达模式与免疫激活过程相符。


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