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发表时间:2018-12-31  浏览次数:145  
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原文:
Schizophrenia is associated with alterations of the immune system. There are, however, only limited data dealing with immune parameters in unmedicated schizophrenic patients and the course of these parameters during treatment. In this study, we monitored CD19+ (B)- and CD3+ (T)-lymphocytes in the course of antipsychotic treatment. Forty patients diagnosed with an acute exacerbation of schizophrenia were tested before and after 3 days, 2 weeks, 4 weeks and 3 months of treatment with antipsychotics. The percentages of CD19+- and CD3+ -lymphocytes were analysed by flow cytometry using fluorescence conjugated anti-CD19 and anti-CD3 antibodies. Twenty healthy volunteers served as controls. In the acute state of psychosis, a significant reduction of the CD3+ -lymphocyte subpopulation was observed, while the percentage of CD19(+)-lymphocytes was increased. Both subpopulations levelled to those of the control group in the course of treatment. As expected, the levels of the immune parameters did not change in the healthy controls during the course of the study. The observed alterations of the CD19+ - and CD3+ -lymphocytes in the acute state of psychosis especially in patients with the paranoid subtype of schizophrenia, and the "normalization" during the observation period are discussed under the aspect of the immune hypothesis of schizophrenia, in particular of the type-1/type-2 imbalance hypothesis.


译文:
精神分裂症与免疫系统变化有关。但未治疗患者及患者接受治疗期间免疫参数方面的数据较为缺乏。本研究对精神分裂症患者服用安定药期间CD19+(B)与CD3+(T)淋巴细胞水平实施监测。研究纳入40名急性精神分裂症加重患者,检测服药前及服药3天、2周、4周与3个月后患者淋巴细胞变化。使用流式细胞术分析CD19+与CD3+淋巴细胞百分比。所用抗体为荧光共轭抗体(抗CD19与CD3)。募集20名健康受试者作为对照。急性精神分裂症患者CD3+淋巴细胞亚群细胞数量明显降低,而CD19+淋巴细胞百分比增加。与对照组相比,均具显著性差异。研究期间,健康受试者免疫参数水平未发生改变,与预期相符。本文就急性精神分裂症患者(尤其是偏执型精神分裂患者)CD19+与CD3+淋巴细胞数量变化及观察期间的“标准化”展开讨论,讨论领域主要针对免疫假说(尤其是1、2型免疫应答失衡假说)。

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