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乳腺炎症翻译样例

发表时间:2018-12-27  浏览次数:96  
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原文:
浆细胞性乳腺炎病因尚不明确,命名也不一致,浆细胞性乳腺炎乳腺炎又称肉芽肿性乳腺炎、乳导管扩张症,非哺乳期乳腺炎。以前有学者认为浆细胞性乳腺炎为厌氧菌感染所致,使病变处感染形成肿块。但近些年的研究倾向浆细胞性乳腺炎乳腺炎为非细菌性所致乳腺炎,经我们临床观察所见浆细胞性乳腺炎患者多数有乳头内陷病史,可能导致乳导管狭窄、阻塞,乳腺分泌物淤积在乳导管内,我们考虑患者长期於乳后刺激乳腺组织导致自身免疫反应发生,而后导致乳房不同部位,甚至对侧乳房出现相同病变。浆细胞性乳腺炎不同于一般的细菌性乳腺炎,对抗生素治疗效果不佳,主要的治疗手段目前还是手术治疗,但术后依旧有复发的可能,这种情况也支持自身免疫性疾病的论点。细菌性乳腺炎小鼠模型现在研究的比较成熟,主要是通过向乳腺内注入菌液诱导炎症产生,本实验不同于细菌性乳腺炎小鼠模型的建立,由取材到接种过程都保持无菌操作,组织经匀浆机匀浆后进一步经细胞粉碎机粉碎以确保没有活体细菌存在的影响,只是借助粉碎后组织内的有效成分诱导浆细胞性乳腺炎的形成,从而排除浆细胞性乳腺炎为细菌引起的炎症反应。
译文:
The pathological mechanism of PCM was still unknown. In addition, several kinds of designation including granulomatous mastitis, mammary duct ectasia or nonlactational mastitis were existed as the unconformity of the designation systems. Previous studies showed anaerobic infection was the main culprit for PCM, resulted in tumorigeness in the infection area. Currently, PCM was reported to be related with nonbacterial infection. Our data indicated most of the PCM patients showed a history of inverted nipples, which might lead to stenosis and obstruction of mammary duct, as well as deposition of secretions (e.g. breast milk) in mammary duct. We speculated long-term deposition of breast milk in mammary duct could stimulate autoimmune response, followed by pathological changes in different parts of mamma. For the treatment of PCM, surgery was still preferred as the antibiotic treatment was not efficient. However, complete recovery was not guaranteed after surgery. To date, bacterial mastitis mouse models were mainly induced by injection of bacterial liquid via lacteal gland. In this study, a PCM mouse model was induced by active ingredient of the PCM tissues. The possibility of bacteria induced PCM was eliminated by sterile processing from sample collection to inoculation and ultrasonic cell disruptor processing after homogenate. Moreover, CFA was used to promote the formation of PCM due to the fact that CFA could stimulate the formation of reservoir antigen pool and local granulomatous complication as well as the proliferation and differentiation of lymphocytes.

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