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肾病药物使用相关翻译

发表时间:2018-12-26  浏览次数:240  
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原文:
Benefits of prednisolone and chlorambucil were maintained for at least 3 years of follow-up. Delaying end-stage renal disease, with its associated cardiovascular risk and increased morbidity and mortality, is of undoubted value to patients with idiopathic membranous nephropathy. However, even in patients given prednisolone and chlorambucil, only 40% had not had a further 20% decline in excretory renal function at 3 years. Clearly, more effective and safer forms of therapy are still needed for idiopathic membranous nephropathy. Until new treatments are available and have been properly tested, the evidence favours use of prednisolone and an alkylating agent in the most severely affected patients. This conclusion, and the lack of good RCTs in nephrology to address this and similar questions, are supported by a Cochrane review of the subject26 and an authoritative review of the international scientific literature on the treatment of glomerulonephritis (panel).
 
译文:
泼尼松龙和苯丁酸氮芥的疗效在接下来至少3年内得到维持。对晚期肾病(及相关的心血管疾病风险和增加的发病率和死亡率)的推迟,无疑对特发性膜性肾病患者具有价值。然而,即使在泼尼松龙与苯丁酸氮芥给药的患者中,只有40%的患者在3年内肾功能下降不超过20%。显然对于特发性膜性肾病,还需要更加有效和安全的治疗方式。在出现新疗法并验证其疗效前,对于多数重症患者,临床证据更倾向于使用泼尼松龙与烷化剂。此结论,以及在肾脏学领域解决此类及类似问题缺乏良好的RCT这一情况,都得到了循证医学关于此课题的综述和另一篇在国际科学文献上关于肾小球性肾炎治疗的权威综述的支持(附注)。

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