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系统化疗翻译

发表时间:2018-12-4  浏览次数:35  
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原文:

Building on this experience, investigators at M.D. Anderson developed a clinical trial of 5-fluorouracil, leucovorin, gemcitabine, and cisplatin (Gem-FLP) for the treatment of patients with metastatic urachal and other adenocarcinomas of the bladder. Early results from this trial in the first group of patients suggest an objective response rate, excluding disease stability, in up to 30%–40% of patients.11 This trial recently completed accrual, and patients are now in long-term follow- up. While additional time is necessary to obtain long-term survival figures, previous data from our institution suggests a median survival in patients with metastatic disease on the order of 24 months2 compared to a median of 12 months at other institutions. Our hope is that this potential difference in outcomes seen in these retrospective studies may reflect the activity of chemotherapy combinations currently in use at M.D.Anderson.

译文:

据此,美国安德森肿瘤医院(M.D. Anderson)制定了Gem-FLP临床治疗方案(5-氟尿嘧啶+甲酰四氢叶酸+吉西他滨+顺铂),以治疗转移性脐尿管癌与其他膀胱腺癌。该项研究第一组患者的早期数据表明,客观应答率高达30%–40%[11]。目前该项研究已结束,正在对患者实施长期随访。为获取存活相关数据,还需要长期随访。我们之前的研究表明,我们院发生转移的该类患者存活期中位数为24个月,其他单位所得存活期中位数为12个月。我们希望通过这些回顾性分析所得结果差异,进而证实在安德森肿瘤医院当前所用化疗方案的有效情况。

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