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治疗方案的制定翻译

发表时间:2018-12-1  浏览次数:57  
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原文:

The treatment schedules were based on best available evidence at the time. All patients received supportive therapy, including renin-angiotensin blockade, statins, and anticoagulants as indicated. Those assigned to supportive therapy plus 6 months’ prednisolone and chorambucil11 received intravenous methyl prednisolone 1 g per day for 3 consecutive days then oral prednisolone 0•5 mg/kg per day for 28 days during months 1, 3, and 5. Intravenous prednisolone was administered in hospital. During months 2, 4, and 6, patients received oral chlorambucil at a starting dose of 0•15 mg/kg per day. We gave this reduced dose because the parent drug and itsmetabolites are renally excreted and our preliminary work had shown that a dose of 0•2 mg/kg per day was poorly tolerated in patients with impaired excretory renal function. We reduced the dose further if the patient developed leucopenia (weekly full blood counts were advised) and interrupted it if leucopenia was severe. 

译文:

治疗方案的制定以当前所得医学依据为基础。所有患者均接受支持治疗,包括肾素血管紧张素系统阻滞、他汀类药物及抗凝血药物。支持治疗联合泼尼松龙+苯丁酸氮芥(服用6个月)组患者每天静脉注射甲泼尼龙1g,持续三天,随后于第1、3、5个月每天口服泼尼松龙(0.5mg/kg),每月持续28天。在医院内实施泼尼松龙静脉注射。第2、4、6个月每天口服苯丁酸氮芥0.15mg/kg。降低药物剂量的原因在于母体药物及代谢产物均通过肾脏排出,且我们之前的研究表明,肾脏排泄功能受损的患者每天服药剂量为0.2 mg/kg时,对药物的耐受性较差。 如患者出现白细胞减少(建议每周进行一次全血计数),则还需进一步降低服药剂量;如白细胞严重减少,建议患者中断研究。

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