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研究相关不良事件翻译

发表时间:2018-11-29  浏览次数:59  
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原文:

Haematological events were leucopenia, anaemia, and thrombocytopenia, although we did not note any lymphomas or leukaemias. Dermatological effects included rash and shingles. Renal effects were mainly deterioration of excretory renal func tion or hyperkalaemia. Neurological effects were tremor and headache. Cardiovascular effects were hypertension, myocardial infarction, chest pain, and pulmonary embolus. Metabolic effects included impairment of glucose tolerance. Gastroenterological effects included nausea, vomiting, diarrhoea, bleeding, and pancreatitis. Infection included septicaemia, pneumonia, and cellulitis. Other effects included cataract, fractured humerus, hernia repairs, and pulmonary sarcoid. We acknowledge that some potential adverse effects of prednisolone plus chlorambucil and ciclosporin are more longlasting than the effects reported with supportive care alone, especially the risk of lymphoma or other malignant diseases.

译文:

本研究中患者报告血液学不良事件包括白细胞减少、贫血、血小板减少症,并未发现淋巴瘤或白血病等不良事件。皮肤不良事件包括皮疹与带状疱疹等。肾脏不良事件主要包括肾功能恶化或高钾血症等。神经学不良事件包括震颤与头疼等。心血管不良事件包括高血压、心肌梗塞、胸痛与肺栓塞等。代谢性不良事件包括葡萄糖耐量受损。胃肠道不良事件包括恶心、呕吐、腹泻、失血及胰腺炎等。研究期间感染包括败血病、肺炎与蜂窝织炎等。其他不良事件包括白内障、肱骨骨折、疝修复与肺结节病等。我们发现,与支持治疗相比,支持治疗联合泼尼松龙+苯丁酸氮芥组潜在不良事件持续周期较长,尤其是患有淋巴瘤或其他恶性病变的风险。

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