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医学翻译—病理学翻译

发表时间:2018-11-27  浏览次数:56  
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原文:

Urachal tumors are nearly always adenocarcinomas and only rarely have sarcomatoid or other urothelial variant histologies been reported. Since the transitional cell epithelium may overlie the urachus, even when there is communication between the bladder and the urachus, it is possible that reports of urothelial histologies of the urachus in actuality reflect a tumor arising from this superficial urothelium rather than a true urachal tumor arising from the urachal ligament. While it may still be appropriate to treat with an urachal ligament controlling surgery, these nonadenocarcinomatous tumors, especially those with transitional cell histology, may respond better to more traditional urothelial-based chemotherapy. Therefore, non-adenocarcinomatous histology should be viewed with caution when making a diagnosis of urachal cancer.

There are two theories regarding the development of urachal tumors. Given their close resemblance to tumors of the colonic or rectal mucosa with frequent glandular structures, mucin production, and colloid or signet-ring cell histology, it is thought that these tumors may arise from enteric rests which are left behind in the cloaca during embryologic development. An alternative proposal is that these tumors may arise from a metaplastic pathway, since adenocarcinomas have been seen to arise from cystitis glandularis and may occur even in upper tract locations, and in extrophic bladders, despite the presence of typical transitional cell epithelium. 
 

译文:

脐尿管肿瘤几乎都是腺癌,只有极少部分报道中出现肉瘤样或其他尿路上皮组织变体。由于移行细胞上皮覆盖在脐尿管上面,即使膀胱和脐尿管之间有沟通,下列情况也是可能的,即脐尿管的尿路上皮组织的报道实际上反映了一种源于这种表面尿路上皮的肿瘤而不是真正的源于脐尿管韧带的脐尿管肿瘤。虽然利用脐尿管韧带控制术进行治疗可能仍然适用,但治疗这类非腺癌性肿瘤,尤其是那些具移行细胞组织的非腺癌性肿瘤,基于尿路上皮的传统化疗方法可能更为有效。因此,诊断脐尿管癌时,应特别关注非腺癌性组织。

关于脐尿管肿瘤的发展有两种理论。由于其与结肠或直肠粘膜层肿瘤非常相似,常见腺体结构、粘蛋白产物和胶状或印戒细胞组织,推测肿瘤可能源于胚胎发生期间泄殖腔左后侧的肠内皮静息细胞。另一种理论提出,肿瘤源于一种转化途径,这是因为已发现有腺癌源于腺性膀胱炎,甚至发生于上泌尿路和膀胱外侧(即便出现典型的移行细胞上皮)。

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