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辅助化疗翻译

发表时间:2018-11-26  浏览次数:49  
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原文:

Currently, there are no standard recommendations regarding adjuvant or neoadjuvant chemotherapy in the treatment of urachal tumors. However, the clinical course of urachal carcinoma more closely resembles the experience with colorectal adenocarcinoma, which is responsive to perioperative 5FUbased chemotherapy. Since we now have an active chemotherapy combination, it seems reasonable to extrapolate from our experience with colorectal perioperative chemotherapy and offer adjuvant chemotherapy to patients at high risk of relapse. There are few long-term survivors in the setting of positive margins, peritoneal carcinomatosis, nodal metastases or when the urachal ligament was not appropriately controlled by en bloc resection with the umbilicus and bladder. MDACC has offered adjuvant chemotherapy with Gem-FLP to those patients who wish to take an aggressive approach owing to their high risk of relapse.

译文:

针对脐尿管癌治疗中选用辅助化疗或新辅助化疗的标准尚未统一。然而,脐尿管癌的临床过程与结肠直肠腺癌密切相关,后者对手术期间基于5FU的化疗有应答。鉴于当前具有主动化疗方案,可以根据结肠直肠手术期间的化疗经验对存在较高复发风险的患者提供辅助化疗。切缘具癌细胞、腹膜转移、淋巴结转移,或脐尿管韧带处理不当的患者,长期存活率很低。针对复发风险高、希望采取积极疗法的患者,MDACC提供Gem-FLP辅助化疗。

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